eFFIcIeNt oNe-Pot sYNtHesIs AND eVALUAtIoN oF tHe cYtotoXIc ActIVItY oF 2,4-DIMetHYL-1H-cHRoMeNo[4',3':4,5] PYRIDo[2,3-D]PYRIMIDINe-1,3,7(2H,4H)-tRIoNe
نویسندگان
چکیده
A 2,4-dimethyl-1H-chromeno[4',3':4,5]pyrido[2,3-d]pyrimidine-1,3,7(2H,4H)-trione 3 was synthesized via a one-pot procedure. Its structure was established on the basis of FTIR, 1H NMR, 13C NMR, DEPT, COSY, HSQC, MS data and elemental analysis. The new compound was assayed for antiproliferative/cytotoxic effects in a panel of human tumor cell lines after 72 h exposure. MTT-dye reduction assay was used as a read-out system and IC50 as an end-point to evaluate efficacy. Our cytotoxicity screening indicates that the presented fused system exhibits moderate antiproliferative effect in a panel of human tumor cell lines of different origin and cellular type.
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